Signal transduction pathway modeling using sequences of chromatophore images.

TitleSignal transduction pathway modeling using sequences of chromatophore images.
Publication TypeJournal Article
Year of Publication2007
AuthorsOrhanovic, I, Crinon, RJ, Chaplen, FWR, Weisshaar, A
JournalIEEE Trans Nanobioscience
Date Published2007 Sep
KeywordsBiosensing Techniques, Cells, Cultured, Chromatophores, Computer Simulation, Image Interpretation, Computer-Assisted, Microscopy, Fluorescence, Microscopy, Video, Models, Biological, Signal Transduction, Subtraction Technique

Extensive research is being done in order to use chromatophore cells as biosensors for various substances. In this paper, a link between the biological aspect of chromatophores and digital image/video processing techniques used for chromatophore characterization is established for this purpose. A model of the Gs--AC--PKA--granule motion-image feature signal transduction pathway is proposed, starting from the concentration of the input ligand and ending in the pigment area extracted from a microscope image. The model extends an existing system biology differential equation based model of the Gs--AC--PKA transduction pathway obtained from the Database of Quantitative Cellular Signaling (DQCS). Examples are presented to demonstrate the effectiveness of the proposed system model.

Alternate JournalIEEE Trans Nanobioscience
PubMed ID17926778