Dr. Jung Y. Kwon
Assistant Professor, Food Science & Technology
Education & Training
B.S. 2004 - Seoul National University, Food Science & Technology
M.S. 2006 - Seoul National University, Food Science & Technology
Ph.D. 2012 - Purdue University, Food Science
Postdoc 2012-2013 - UC Berkeley, Nutritional Sciences & Toxicology
Postdoc 2014-2016 - UMass Medical School, Program in Molecular Medicine
Biological functions of natural dietary molecules derived from marine resources in health promotion and disease prevention. Research interest includes identifying marine-derived bioactive compounds with beneficial effects in obesity and associated metabolic syndrome focusing on the regulation of lipid metabolism and inflammation in adipose tissue; uncovering potential health value of seafood materials and underutilized aquatic resources to promote efficient utilization of the harvested resources.
Dagdeviren S, Jung DY, Friedline RH, Noh HL, Kim JH, Patel PR, Tsitsilianos N, Inashima K, Tran DA, Hu X, Loubato MM, Craige SM, Kwon JY, Lee KW, Kim JK. IL-10 prevents aging-associated inflammation and insulin resistance in skeletal muscle. FASEB J. 2017 Feb;31(2):701-710.
Dagdeviren S, Jung DY, Lee E, Friedline RH, Noh HL, Kim JH, Patel PR, Tsitsilianos N, Tsitsilianos AV, Tran DA, Tsougranis GH, Kearns CC, Uong CP, Kwon JY, Muller W, Lee KW, Kim JK. Altered Interleukin-10 Signaling in Skeletal Muscle Regulates Obesity-Mediated Inflammation and Insulin Resistance. Mol Cell Biol. 2016 Nov 14;36(23):2956-2966.
Kang H, Lee CH, Kim JR, Kwon JY, Son MJ, Kim JE, Lee KW. Theobroma cacao extract attenuates the development of Dermatophagoides farinae-induced atopic dermatitis-like symptoms in NC/Nga mice. Food Chem. 2017 Feb 1;216:19-26
Methionine deprivation suppresses triple-negative breast cancer metastasis in vitro and in vivo. Jeon H, Kim JH, Lee E, Jang YJ, Son JE, Kwon JY, Lim TG, Kim S, Park JH, Kim JE, Lee KW. Oncotarget. 2016 Oct 11;7(41):67223-67234
Kwon JY, Byun SG, Lee KW. Proteomics in Understanding the Molecular Basis of Phytochemicals for Health. Genomics, Proteomics and Metabolomics in Nutraceuticals & Functional Foods (2nd Edition). 2015 August 14.
Kang H, Lee CH, Kim JR, Kwon JY, Seo SG, Han JG, Kim BG, Kim JE, Lee KW. Chlorella vulgaris Attenuates Dermatophagoides Farinae-Induced Atopic Dermatitis-Like Symptoms in NC/Nga Mice. Int J Mol Sci. 2015 Sep 2;16(9):21021-34.
Lee E, Jung DY, Kim JH, Patel PR, Hu X, Lee Y, Azuma Y, Wang HF, Tsitsilianos N, Shafiq U, Kwon JY, Lee HJ, Lee KW, Kim JK. Transient receptor potential vanilloid type-1 channel regulates diet-induced obesity, insulin resistance, and leptin resistance. FASEB J. 2015 Aug;29(8):3182-92.
Cheong LY, Suk S, Thimmegowda NR, Chung MY, Yang H, Seo SG, Shwetha B, Kim JE, Kwon JY, Kim BY, Lee KW. Hirsutenone Directly Targets PI3K and ERK to Inhibit Adipogenesis in 3T3-L1 Preadipocytes. J Cell Biochem. 2015 Jul;116(7):1361-70
Roh E, Kim JE, Kwon JY, Park JS, Bode AM, Dong Z, Lee KW. Molecular Mechanisms of Green Tea Polyphenols with Protective Effects against Skin Photoaging. Crit Rev Food Sci Nutr. 2015 Jun 26. [Epub ahead of print]
Huh WB, Kim JE, Kang YG, Park G, Lim TG, Kwon JY, Song da S, Jeong EH, Lee CC, Son JE, Seo SG, Lee E, Kim JR, Lee CY, Park JS, Lee KW. Brown Pine Leaf Extract and Its Active Component Trans-Communic Acid Inhibit UVB-Induced MMP-1 Expression by Targeting PI3K. PLoS One. 2015 Jun 11;10(6):e0128365.
Lim TG, Jeon AJ, Yoon JH, Song D, Kim JE, Kwon JY, Kim JR, Kang NJ, Park JS, Yeom MH, Oh DK, Lim Y, Lee CC, Lee CY, Lee KW. 20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol, a metabolite of ginsenoside Rb1, enhances the production of hyaluronic acid through the activation of ERK and Akt mediated by Src tyrosin kinase in human keratinocytes. Int J Mol Med. 2015 May;35(5):1388-94
Kim KH, Kwon JY, Chen C, Komanetsky S, Zhu Y, Kershaw J. Piceatannol Inhibits Lipolysis in Adipocytes by promoting autophagy-lysosome-induced degradation of Lipolytic Proteins. FASEB J. 2015 April;29(1):Supple248.6
Shin SH, Seo SG, Min S, Yang H, Lee E, Son JE, Kwon JY, Yue S, Chung MY, Kim KH, Cheng JX, Lee HJ, Lee KW. Caffeic acid phenethyl ester, a major component of propolis, suppresses high fat diet-induced obesity through inhibiting adipogenesis at the mitotic clonal expansion stage. J Agric Food Chem. 2014 May 14;62(19):4306-12.
Seo SG, Yang H, Shin SH, Min S, Kim YA, Yu JG, Lee DE, Chung MY, Heo YS, Kwon JY, Yue S, Kim KH, Cheng JX, Lee KW, Lee HJ. A metabolite of daidzein, 6,7,4'-trihydroxyisoflavone, suppresses adipogenesis in 3T3-L1 preadipocytes via ATP-competitive inhibition of PI3K. Mol Nutr Food Res. 2013 Aug;57(8):1446-55.
Kwon JY, Seo SG, Yue S, Cheng JX, Lee KW, Kim KH. An inhibitory effect of resveratrol in the mitotic clonal expansion and insulin signaling pathway in the early phase of adipogenesis. Nurt Res. 2012 Aug;32(8):607-16.
Song NR, Yang H, Park J, Kwon JY, Kang NJ, Heo YS, Lee KW, Lee HJ. Cyanidin suppresses neoplastic cell transformation by directly targeting phosphatidylinositol 3-kinase. Food Chem. 2012 Aug 1;133(3): 658–64
Kwon JY, Seo SG, Heo YS, Yue S, Cheng JX, Lee KW, Kim KH. Piceatannol, a natural polyphenolic stilbene, inhibits adipogenesis via modulation of mitotic clonal expansion and insulin receptor-dependent insulin signaling in the early phase of differentiation. J Biol Chem. 2012 Mar 30;287(14):11566-78.
Lim TG, Kwon JY, Kim J, Song NR, Lee KM, Heo YS, Lee HJ, Lee KW. Cyanidin-3-glucoside suppresses B[a]PDE-induced cyclooxygenase-2 expression by directly inhibiting Fyn kinase activity. Biochem Pharmacol. 2011 Jul 15;82(2):167-74.
Lim TG, Lee BK, Kwon JY, Jung SK, Lee KW. Acrylamide up-regulates cyclooxygenase-2 expression through the MEK/ERK signaling pathway in mouse epidermal cells. Food Chem Toxicol. 2011 Jun;49(6):1249-54.
Kim JE, Kwon JY (Co-first), Seo SK, Son JE, Jung SK, Min SY, Hwang MK, Heo YS, Lee KW, Lee HJ. Cyanidin suppresses ultraviolet B-induced COX-2 expression in epidermal cells by targeting MKK4, MEK1, and Raf-1. Biochem Pharmacol. 2010 May 15;79(10):1473-82.
Kwon JY, Lee KW, Kim JE, Jung SK, Kang NJ, Hwang MK, Heo YS, Bode AM, Dong Z, Lee HJ. Delphinidin suppresses ultraviolet B-induced cyclooxygenase-2 expression through inhibition of MAPKK4 and PI-3 kinase. Carcinogenesis 2009 Nov;30(11):1932-40.
Kim MS, Kwon JY, Kang NJ, Lee KW, Lee HJ. Phloretin induces apoptosis in H-Ras MCF10A human breast tumor cells through the activation of p53 via JNK and p38 mitogen-activated protein kinase signaling. Ann N Y Acad Sci. 2009 Aug;1171:479-83.
Kang NJ, Lee KW, Kwon JY, Hwang MK, Rogozin EA, Heo YS, Bode AM, Lee HJ, Dong Z. Delphinidin attenuates neoplastic transformation in JB6 Cl41 mouse epidermal cells by blocking Raf/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signaling. Cancer Prev Res. 2008 Dec;1(7):522-31.
Kim JE, Kwon JY, Lee DE, Kang NJ, Heo YS, Lee KW, Lee HJ. MKK4 is a novel target for the inhibition of tumor necrosis factor-alpha-induced vascular endothelial growth factor expression by myricetin. Biochem Pharmacol. 2009 Feb 1;77(3):412-21.
Lee KM, Kwon JY, Lee KW, Lee HJ. Ascorbic acid 6-palmitate suppresses gap-junctional intercellular communication through phosphorylation of connexin 43 via activation of the MEK-ERK pathway. Mutat Res. 2009 Jan 15;660(1-2):51-6.
Kang NJ, Lee KM, Kim JH, Lee BK, Kwon JY, Lee KW, Lee HJ. Inhibition of gap junctional intercellular communication by the green tea polyphenol (-)-epigallocatechin gallate in normal rat liver epithelial cells. J Agric Food Chem. 2008 Nov 12;56(21):10422-7.
Kwon JY, Lee KW, Lee HJ. Eupatilin inhibits the phenazine methosulfate-induced inhibition of gap junctional intercellular communication and activation of matrix metalloproteinase-2 through the attenuation of reactive oxygen species. J. Clin. Biochem. Nutr., Supple. 2008 Jun;43:1-5
Kim JS, Lee GG, Kim J, Kwon JY, Kwon ST. The development of rapid real-time PCR detection system for Vibrio parahaemolyticus in raw oyster. Lett Appl Microbiol. 2008 Jun;46(6):649-54.
Kwon JY, Lee KW, Hur HJ, Lee HJ. Peonidin inhibits phorbol-ester-induced COX-2 expression and transformation in JB6 P+ cells by blocking phosphorylation of ERK-1 and -2. Ann N Y Acad Sci. 2007 Jan;1095:513-20.